Acetate → HCID 86587065, compound

HRID 351513Notes

Reaction equation

HRID 351513 reaction equation
[CH2:1]([O:3][CH:4]([CH2:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[CH:17][CH:16]=1)[C:5]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[O:6])[CH3:2].P([O-])([O-])([O-])=O.C([O-])(=O)C>>[CH2:1]([O:3][C@@H:4]([CH2:14][C:15]1[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=1)[C:5]([OH:7])=[O:6])[CH3:2].[CH2:1]([O:3][C@H:4]([CH2:14][C:15]1[CH:16]=[CH:17][C:18]([OH:21])=[CH:19][CH:20]=1)[C:5]([O:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH3:13])=[O:6])[CH3:2]

Participants

4

Reactant 3

HCID 175AcetateHCID 1061PhosphateHCID 85044960HCID 85044960, compound

Product 1

HCID 86587065HCID 86587065, compound

Procedure

To hexyl (2RS) (+/−) 2-ethoxy-3-(4-hydroxyphenyl)propanoate (0.5 ml of a solution containing 2 mg/ml in a phosphate, pH 7; 0.1M, or acetate buffer, pH 5; 0.1 M) was added the enzyme (0.5 ml enzyme solution). The reaction mixture was shaken at room temperature and analysed at different times (maximum 30 h). The reaction mixture was analysed by the gradient HPLC method 1, and the chiral CE method 1.

Workup

  1. customanalysed at different times (maximum 30 h)

Sources & evidence

ORD record
ord-252279e99628417494edb7b0c440d882
Source dataset
uspto-grants-2004_06
Patent number
US06743608B2

Reaction notes

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