Acetonitrile → HCID 86587062, compound

HRID 351516Notes

Reaction equation

HRID 351516 reaction equation
[CH2:1]([O:3][CH:4]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1)[C:5]([O:7][CH:8]([CH3:10])[CH3:9])=[O:6])[CH3:2].C(#N)C>P([O-])([O-])([O-])=O>[CH2:1]([O:3][C@@H:4]([CH2:11][C:12]1[CH:13]=[CH:14][C:15]([OH:18])=[CH:16][CH:17]=1)[C:5]([OH:7])=[O:6])[CH3:2].[CH2:1]([O:3][C@H:4]([CH2:11][C:12]1[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=1)[C:5]([O:7][CH:8]([CH3:10])[CH3:9])=[O:6])[CH3:2]

Participants

4

Reactant 2

HCID 6342AcetonitrileHCID 68679680HCID 68679680, compound

Product 1

HCID 86587062HCID 86587062, compound

Reagents, catalysts & solvents 1

HCID 1061PhosphateSolvent2×

Procedure

To isopropyl (2RS) (+/−) 2-ethoxy-3-(4-hydroxyphenyl)-propanoate (0.25 ml of a solution containing 2 mg/ml in phosphate buffer 0.1 M pH 7 and acetonitrile 10% (v/v)) was added the enzyme (amount indicated below) diluted in phosphate buffer 0.1M pH 7 (buffer volume such as total reaction mixture volume was 0.5 ml). The reaction mixture was shaken at room temperature and analysed at different times. The reaction mixture was analysed by the gradient HPLC method 1, and the chiral CE method 2.

Workup

  1. additionwas added the enzyme (amount indicated below)

Sources & evidence

ORD record
ord-adb27ec00f9a43959c3e33620d674a15
Source dataset
uspto-grants-2004_06
Patent number
US06743608B2

Reaction notes

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