Ethoxyethyl (2rs) 2-ethoxy-3-(4-hydroxyphenyl)propanoate → HCID 86587059, compound

HRID 351517Notes

Reaction equation

HRID 351517 reaction equation
[CH2:1]([O:3][CH:4]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1)[C:5]([O:7][CH2:8][CH2:9][O:10][CH2:11][CH3:12])=[O:6])[CH3:2]>P([O-])([O-])([O-])=O>[CH2:1]([O:3][C@@H:4]([CH2:13][C:14]1[CH:15]=[CH:16][C:17]([OH:20])=[CH:18][CH:19]=1)[C:5]([OH:7])=[O:6])[CH3:2].[CH2:1]([O:3][C@H:4]([CH2:13][C:14]1[CH:19]=[CH:18][C:17]([OH:20])=[CH:16][CH:15]=1)[C:5]([O:7][CH2:8][CH2:9][O:10][CH2:11][CH3:12])=[O:6])[CH3:2]

Participants

3

Reactant 1

HCID 90876134Ethoxyethyl (2rs) 2-ethoxy-3-(4-hydroxyphenyl)propanoate

Product 1

HCID 86587059HCID 86587059, compound

Reagents, catalysts & solvents 1

HCID 1061PhosphateSolvent2×

Procedure

To ethoxyethyl (2RS) (+/−) 2-ethoxy-3-(4-hydroxyphenyl)-propanoate (0.25 ml of a solution containing 2 mg/ml in phosphate buffer 0.1M pH 7) was added the enzyme (amount indicated below) diluted in phosphate buffer 0.1M pH 7 (buffer volume such as total reaction mixture volume was 0.5 ml). The reaction mixture was shaken at room temperature and analysed at different times. The reaction mixture was analysed by the gradient HPLC method 1, and the chiral CE method 2.

Workup

  1. additionwas added the enzyme (amount indicated below)

Sources & evidence

ORD record
ord-de1de0c3b1544fd0ad41c41e488f99f7
Source dataset
uspto-grants-2004_06
Patent number
US06743608B2

Reaction notes

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