Lipoamide → n-Hexyl (2R)-2-Ethoxy-3-(4-hydroxyphenyl)propanoate Ethyl (2S)-2-Ethoxy-3-(4-hydroxyphenyl)propanoate

Participants

Reaction Steps

To a solution of ethyl (2RS) (+/−) 2-ethoxy-3-(4-hydroxyphenyl)propanoate in t-butyl ethyl ether (dried on 3 Å molecular sieve) (10 mg/ml) was added n-hexanol (2 equivalents), triethylamine (dried on 3 Å molecular sieve) (14 mol %), 4 Å molecular sieve, and Mucor miehei lipase Lipozyme IM (from Novo Nordisk) (20 mg). The reaction mixture was shaken at room temperature and analysed at different times. The reaction mixture was analysed by the gradient HPLC method 1 and by the chiral CE method 2.

Provenance & Evidence