Hydrochloric Acid → HCID 69818263, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-[4-(3-hydroxyphenyl)piperazin-1-yl]benzoic acid dihydrobromide (2.396 g) in a mixture of 5% NaOH aq. (16.7 ml) and dimethylsulfoxide (33.3 ml) was stirred for 30 minutes at 80° C. Then, 1-bromohexane (0.88 ml) was added thereto and stirred for 8 hours at 80° C. The reaction mixture was added to water and adjusted to pH 2.0 with 1N HCl. The produced precipitate was collected by filtration and dried under reduced pressure to give 4-[4-(3-hexyloxyphenyl)piperazin-1-yl]benzoic acid hydrochloride (3.74 g).

Provenance & Evidence