HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-[4-(4-Hexyloxyphenyl)piperazin-1-yl]benzoic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Ethyl 4-[4-(4-hexyloxyphenyl)piperazin-1-yl]benzoate | HCID 22713156 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-[4-(4-Hexyloxyphenyl)piperazin-1-yl]benzoic acid hydrochloride | HCID 69818033 | — |
Reaction Steps
To a solution of ethyl 4-[4-(4-hexyloxyphenyl)piperazin-1-yl]benzoate (2.19 g) in the mixture of ethanol (22 ml) and tetrahydrofuran (22 ml) was added 2N NaOH aq. and refluxed for 5 hours. The reaction mixture was adjusted to pH 1-1.5 with 1N HCl and the resulting precipitate was collected by filtration to give 4-[4-(4-hexyloxyphenyl)piperazin-1-yl]benzoic acid hydrochloride (1.99 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743776B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-3e86966a8f3f47a7befd4b1e441bb695 |
| Source note | uspto-grants-2004_06 |