HuagongsheHuagongshe Chemistry Print Report · For research reference only
5,7-dihydro-6H-dibenz[c,e]azepine-6carbonitrile → 2-butyl 5,7-dihydro-6H-dibenz[c,e]azepine-6-thiocarboximidate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5,7-dihydro-6H-dibenz[c,e]azepine-6carbonitrile | HCID 19833886 | — |
| Reactant | Sodium 2-butanethiolate | HCID 23677270 | — |
| Solvent | 2-Butanethiol | HCID 10560 | — |
| Product | 2-butyl 5,7-dihydro-6H-dibenz[c,e]azepine-6-thiocarboximidate | HCID 20041715 | — |
Reaction Steps
starting from 5,7-dihydro-6H-dibenz[c,e]azepine-6-carbonitrile and sodium 2-butanethiolate in 2-butanethiol there is obtained 2-butyl 5,7-dihydro-6H-dibenz[c,e]azepine-6-thiocarboximidate which is purified by flash chromatography on silica gel using n-hexane/ethyl acetate (1:1) as the eluent, 1H-NMR(CDCl3): 1.05 (t, CH2CH3), 1.42 (d, CH--CH3), 1.46-1.93 (m, CH2CH3), 2.81-3.37 (m, 1H), 4.41 (s, 4H), 5.1 (broad s, NH), 7.37-7.70 (8H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04766115 |
| Source dataset | uspto-grants-1988_08 |
| ORD ID | ord-1d258d13429b4f9f9d280c93aaae0aba |
| Source note | uspto-grants-1988_08 |