Water → HCID 15521678, compound

Participants

Reaction Steps

A solution of 4-aminobenzonitrile (2.3 g, 0.0195 mol) and N,N′-carbonyldiimidazole (3.5 g, 0.332 mol) in DMF (20 ml) was heated at 80° C. for 7 hours (h). A solution of L-alanine ethyl ester (3 g, 0.0195 mol) in DMF (15 ml) was added and stirring was continued for 3 days (d) at 80° C. Water (300 ml) was added and the precipitate was filtered off (giving 750 mg of the dimer as side product). The solution was extracted with ethyl acetate to give 3 g of the title compound which contained the corresponding acid as side product. MS (mass spectrometry) peak was at 262.1 (M+1)+.

Provenance & Evidence