Water → HCID 22713342, compound

Participants

Reaction Steps

To a solution of 4-fluorophenyl-4-tolylsulfone (1.25 g, 5 mmol) in N,N′-dimethylpropyleneurea (5 ml) was added 1,4-dioxa-8-aza-spiro[4.5]decane (0.88 g, 6 mmol), and potassium carbonate (0.83 g, 6 mmol). The mixture was stirred at room temperature for 4 h and then heated at 70° C. for 18 h. An additional 0.22 g of 1,4-dioxa-8-aza-spiro[4.5]decane was added, and the reaction was continued for 1 day. The mixture was cooled to room temperature, and treated with water. The resulting suspension was filtered, and the precipitate washed with water and methanol, and dried in vacuo to give 1.80 g of a white solid; m.p. 164-165° C.; MS (ES) m/z 373.9 (MH+); HRMS (EI) Calcd. for C20H23NO4S (M+): 373.1348, Found: 373.1342.

Provenance & Evidence