1,4-Dioxa-8-azaspiro(4.5)decane → HCID 22713327, compound

HRID 351688Notes

Reaction equation

HRID 351688 reaction equation
[O:1]1[C:5]2([CH2:10][CH2:9][NH:8][CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1.F[C:12]1[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][CH2:23][OH:24])(=[O:20])=[O:19])=[CH:14][CH:13]=1>>[O:1]1[C:5]2([CH2:10][CH2:9][N:8]([C:12]3[CH:17]=[CH:16][C:15]([S:18]([NH:21][CH2:22][CH2:23][OH:24])(=[O:20])=[O:19])=[CH:14][CH:13]=3)[CH2:7][CH2:6]2)[O:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 674351,4-Dioxa-8-azaspiro(4.5)decaneHCID 15876834-Fluoro-N-(2-hydroxyethyl)benzenesulfonamide

Product 1

HCID 22713327HCID 22713327, compound

Procedure

The title compound was prepared according to the procedure of Intermediate 24 from 2.28 g (15.6 mmol) of 1,4-dioxa-8-aza-spiro[4.5]decane and 2.85 g (13.0 mmol) of 4-fluoro-N-(2-hydroxyethyl)-benzenesulfonamide, yielding 3.0 g of a colorless gum; MS (ES) m/z 343.2 (MH+); HRMS (EI) Calcd. for C15H22N2O5S (M+): 342.1249, Found: 342.1235.

Sources & evidence

ORD record
ord-5421c2fe343743d9956797a2fb3160fc
Source dataset
uspto-grants-2004_06
Patent number
US06743787B2

Reaction notes

Loading…