HRID351711

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12047933

未命名化合物

结构：Cc1ccc(S(=O)(=O)c2ccc(N3CCC(=O)CC3)cc2)cc1

HCID22713358

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)c2ccc(N3CCC(NCC(O)c4ccc(O)c(NS(C)(=O)=O)c4)CC3)cc2)cc1

HCID10281140

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the procedure of Example 1 from 0.13 g (0.4 mmol) of Reference Example 25, 1-[4-(Toluene-4-sulfonyl)-phenyl]-piperidin-4-one, and 0.12 g (0.5 mmol) of (R)-N-[5-(2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl}-methanesulfonamide, yielding 0.18 g of a white solid; m.p. 115-118° C.; MS (ES) m/z 560.0 (MH+); HRMS (FAB) Calcd. for C27H34N3O6S2 (MH+): 560.1889, Found: 560.1886.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-45aab5adea28444da76aaa8b98e2677c
来源数据集: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06743787B2
来源说明: uspto-grants-2004_06

反应 SMILES

[C:1]1([CH3:23])[CH:6]=[CH:5][C:4]([S:7]([C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][C:19](=O)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[NH2:24][CH2:25][C@@H:26]([C:28]1[CH:29]=[CH:30][C:31]([OH:39])=[C:32]([NH:34][S:35]([CH3:38])(=[O:37])=[O:36])[CH:33]=1)[OH:27]>>[OH:39][C:31]1[CH:30]=[CH:29][C:28]([CH:26]([OH:27])[CH2:25][NH:24][CH:19]2[CH2:20][CH2:21][N:16]([C:13]3[CH:12]=[CH:11][C:10]([S:7]([C:4]4[CH:5]=[CH:6][C:1]([CH3:23])=[CH:2][CH:3]=4)(=[O:8])=[O:9])=[CH:15][CH:14]=3)[CH2:17][CH2:18]2)=[CH:33][C:32]=1[NH:34][S:35]([CH3:38])(=[O:37])=[O:36]