HRID351712

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID10799105

未命名化合物

结构：Cc1ccc(S(=O)(=O)c2ccc(N3CCC(=O)CC3)cc2)cc1

HCID22713358

未命名化合物

PRODUCTS

生成物

结构：Cc1ccc(S(=O)(=O)c2ccc(N3CCC(NC[C@H](O)COc4cccc5[nH]c(=O)[nH]c45)CC3)cc2)cc1

HCID10302251

未命名化合物

PROCEDURE

实验过程

The title compound was prepared according to the procedure of Example 1 from 0.13 g (0.4 mmol) of Reference Example 25, 1-[4-(toluene-4-sulfonyl)-phenyl]-piperidin-4-one, and 0.13 g (0.6 mmol) of 4-((2S)-3-Amino-2-hydroxy-propoxy)-1,3-dihydro-benzoimidazol-2-one, yielding 0.18 g of a white solid; m.p. 130-132° C.; MS (ES) m/z 537.0 (MH+); HRMS (FAB) Calcd. for C28H33N4O5S (MH+): 537.2166, Found: 537.2169.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-3c6c9433e3f54bd999eefdbed69e6758
来源数据集: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06743787B2
来源说明: uspto-grants-2004_06

反应 SMILES

[C:1]1([CH3:23])[CH:6]=[CH:5][C:4]([S:7]([C:10]2[CH:15]=[CH:14][C:13]([N:16]3[CH2:21][CH2:20][C:19](=O)[CH2:18][CH2:17]3)=[CH:12][CH:11]=2)(=[O:9])=[O:8])=[CH:3][CH:2]=1.[NH2:24][CH2:25][C@H:26]([OH:39])[CH2:27][O:28][C:29]1[C:37]2[NH:36][C:35](=[O:38])[NH:34][C:33]=2[CH:32]=[CH:31][CH:30]=1>>[OH:39][C@@H:26]([CH2:25][NH:24][CH:19]1[CH2:20][CH2:21][N:16]([C:13]2[CH:12]=[CH:11][C:10]([S:7]([C:4]3[CH:3]=[CH:2][C:1]([CH3:23])=[CH:6][CH:5]=3)(=[O:9])=[O:8])=[CH:15][CH:14]=2)[CH2:17][CH2:18]1)[CH2:27][O:28][C:29]1[C:37]2[NH:36][C:35](=[O:38])[NH:34][C:33]=2[CH:32]=[CH:31][CH:30]=1