(R)-N-(5-(2-amino-1-hydroxyethyl)-2-hydroxyphenyl)methanesulfonamide → HCID 10305415, compound

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Reaction Steps

The title compound was prepared according to the procedure of Example 1 from 0.37 g (0.8 mmol) of Reference Example 27, 2-But-2-ynyl-2-[4-(4-oxo-piperidin-1-yl)-benzenesulfonyl]-hex-4-ynoic acid tert-butyl ester, and 0.24 g (1.0 mmol) of (R)-N-[5-(2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl)-methanesulfonamide, yielding 0.54 g of an off-white solid; m.p. 93-95° C.; MS (ES) m/z 688.2 (MH+); HRMS (ES) Calcd. for C34H46N3O8S2 (MH+): 688.2721, Found: 688.2722.

Provenance & Evidence