Oxalyl chloride → 2-(2-furyl)quinoline-4-carbonyl Chloride

Participants

Role	Name	HCID	Charge
Reactant	Oxalyl chloride	HCID 65578	—
Reactant	2-(Furan-2-yl)quinoline-4-carboxylic acid	HCID 697640	—
Solvent	Dichloromethane	HCID 6344	—
Product	2-(2-furyl)quinoline-4-carbonyl Chloride	HCID 10634911	100.6%

Reaction Conditions

Temperature	-10 °C

Reaction Steps

5.2 ml (60.4 mmol) of oxalyl chloride were dissolved in 70 ml of CH2Cl2. The solution was cooled at −10° C. and 8.5 g (35.5 mmol) of 2-(2-furyl)quinoline-4-carboxylic acid were added portionwise. The reaction mixture was left overnight at room temperature and then evaporated to dryness to yield 9.2 g of the title compound, used without further purification.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06743804B2
Source dataset	uspto-grants-2004_06
ORD ID	ord-462d34639e114df18519164b40748a2f
Source note	uspto-grants-2004_06