反应详情

The crude product from Step 1 was dissolved in methanol (12 mL/mmol) and 1N aqueous sodium hydroxide was added (3 eq), resulting in a suspension. The suspension mixture was stirred at room temperature for 2 hours and the methanol was evaporated. The resulting aqueous suspension was diluted with water and the product was extracted out with ethyl acetate. The crude product was chromatographed on silica gel eluting with 10% ether in methylene chloride to afford the N-isopropyl-1-(3-ethynylphenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide compound as a solid.

1. customresulting in a suspension
2. customthe methanol was evaporated
3. additionThe resulting aqueous suspension was diluted with water
4. extractionthe product was extracted out with ethyl acetate
5. customThe crude product was chromatographed on silica gel eluting with 10% ether in methylene chloride