HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenylacetylene → N-cyclopropyl-4-oxo-1-(3-(2-(pyridin-3-yl)ethynyl)phenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenylacetylene | HCID 10821 | — |
| Reactant | 3-Bromopyridine | HCID 12286 | — |
| Reactant | 1-(3-bromophenyl)-N-isopropyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide | HCID 12991318 | — |
| Product | N-cyclopropyl-4-oxo-1-(3-(2-(pyridin-3-yl)ethynyl)phenyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide | HCID 10136016 | — |
Reaction Steps
Following the procedure of Step 5 of EXAMPLE 1, but substituting N-cyclopropyl-1-(3-ethynylphenyl)- 1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide from EXAMPLE 6 for phenylacetylene and 3-bromopyridine for N-isopropyl-1-(3-bromophenyl)-1,4-dihydro[1,8]naphthyridin4-one-3-carboxamide, the title compound was obtained as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743802B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-4f7cb8f95107489ca81bbf7c0314197a |
| Source note | uspto-grants-2004_06 |