HRID351741

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID92098

2-Phenylbut-3-yn-2-ol

C10H10O

结构：CC(C)NC(=O)c1cn(-c2cccc(Br)c2)c2ncccc2c1=O

HCID12991318

未命名化合物

HCID22714295

未命名化合物

PRODUCTS

生成物

结构：CC(C)NC(=O)c1cn(-c2cccc(C#Cc3cc(C(C)(C)O)c[n+]([O-])c3)c2)c2ncccc2c1=O

HCID10184463

未命名化合物

PROCEDURE

实验过程

Following the procedure of EXAMPLE 15, but substituting N-isopropyl-1-(3-ethynylphenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide from EXAMPLE 5 for 2-phenyl-3-butyn-2-ol, and 3-bromo-5-(1-hydroxy-1-methylethyl)pyridine-N-oxide from Step 2 for N-isopropyl-1-(3-bromophenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide, the N-isopropyl-1-{3-[5-(1-hydroxy-1-methylethyl)-1-oxido-3-pyridinylethynyl]phenyl}-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide compound was obtained as a solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-2c30c522d0dd4b3c8d46a5d294d2e2e3
来源数据集: uspto-grants-2004_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06743802B2
来源说明: uspto-grants-2004_06

反应 SMILES

[C:1]1([C:7](O)([C:9]#[CH:10])C)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.BrC1[CH:14]=[N+:15]([O-:23])[CH:16]=[C:17]([C:19]([OH:22])([CH3:21])[CH3:20])[CH:18]=1.[CH:24]([NH:27][C:28]([C:30]1[C:39](=[O:40])[C:38]2[C:33](=[N:34][CH:35]=[CH:36][CH:37]=2)[N:32](C2C=CC=C(Br)C=2)[CH:31]=1)=[O:29])([CH3:26])[CH3:25]>>[CH:24]([NH:27][C:28]([C:30]1[C:39](=[O:40])[C:38]2[C:33](=[N:34][CH:35]=[CH:36][CH:37]=2)[N:32]([C:5]2[CH:4]=[CH:3][CH:2]=[C:1]([C:7]#[C:9][C:10]3[CH:14]=[N+:15]([O-:23])[CH:16]=[C:17]([C:19]([OH:22])([CH3:21])[CH3:20])[CH:18]=3)[CH:6]=2)[CH:31]=1)=[O:29])([CH3:25])[CH3:26]