HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Bromoquinoline → 1-[3-(1-Oxido-3-pyridinylethynyl)phenyl]-1,4-dihydro[1,8]naphthyridin4-one-3-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Bromoquinoline | HCID 21413 | — |
| Reactant | Pyridine, 3-bromo-, 1-oxide | HCID 142763 | — |
| Reactant | n-Isopropyl-1-(3-ethynylphenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide | HCID 9880627 | — |
| Product | 1-[3-(1-Oxido-3-pyridinylethynyl)phenyl]-1,4-dihydro[1,8]naphthyridin4-one-3-carboxamide | HCID 10271233 | — |
Reaction Steps
Following the procedure of example 19, but substituting the 1-(3-ethynylphenyl)-1,4-dihydro[1,8]naphthyridin4-one-3-carboxamide from Step 3 for N-Isopropyl-1-(3-ethynylphenyl)-1,4-dihydro[1,8]naphthyridin-4-one-3-carboxamide and 3-bromopyridine N-oxide for 3-bromoquinoline, the 1-[3-(1-oxido-3-pyridinylethynyl)phenyl]-1,4-dihydro[1,8]naphthyridin4-one-3-carboxamide was obtained as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743802B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-9139c5fdfcae4e40b8253295c836134e |
| Source note | uspto-grants-2004_06 |