Potassium Carbonate → HCID 12993970, compound

Participants

Reaction Steps

7.5 g of 3,8-dioxa-1,6-diazaspiro[4,4]nona-1,6-diene-2,7-dithiol, 7.5 g of 4-bromo-1,1,2-trifluoro-1-butene and 7.0 g of potassium carbonate were added to 200 ml of acetonitrile and refluxed for 5 hours. The reaction mixture was cooled to room temperature and filtered by sucction and the filtrate was distilled under reduced pressure. The residue was purified by column chromatography (eluent: ethyl acetate:dichloromethane=1:4) to obtain 7.0 g of 4-hydroxymethyl-2-(3,4,4-trifluoro-3-butenylthio)oxazole as colorless oil (yield 74.2%). n20D=1.4910.

Provenance & Evidence