Allyl bromide → 6-(3,4-Dihydro-4-methanesulfonyl-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydro-2-(2-propenyl)pyridazin-3-one

HRID 35182Notes

Reaction equation

HRID 35182 reaction equation
[CH3:1][S:2]([N:5]1[C:10]2[CH:11]=[C:12]([C:15]3[CH2:16][CH2:17][C:18](=[O:21])[NH:19][N:20]=3)[CH:13]=[CH:14][C:9]=2[O:8][CH2:7][CH2:6]1)(=[O:4])=[O:3].[CH2:22](Br)[CH:23]=[CH2:24]>>[CH3:1][S:2]([N:5]1[C:10]2[CH:11]=[C:12]([C:15]3[CH2:16][CH2:17][C:18](=[O:21])[N:19]([CH2:24][CH:23]=[CH2:22])[N:20]=3)[CH:13]=[CH:14][C:9]=2[O:8][CH2:7][CH2:6]1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 7841Allyl bromideHCID 14230055HCID 14230055, compound

Product 1

HCID 155994066-(3,4-Dihydro-4-methanesulfonyl-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydro-2-(2-propenyl)pyridazin-3-one

Procedure

6-(3,4-Dihydro-4-methanesulfonyl-1,4(2H)-benzoxazin-6-yl)-2,3,4,5-tetrahydropyridazin-3-one was reacted with allyl bromide instead of methyl iodide, following the procedure of Example 9. The title compound was recovered, yield 2.03 g, mp 153°-155° C.

Workup

  1. customThe title compound was recovered

Sources & evidence

ORD record
ord-9f07261beadd4f4bb6d0226538e98cf2
Source dataset
uspto-grants-1988_08
Patent number
US04766118

Reaction notes

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