反应详情

温度

150 °C

A suspension of 6-methyl-2H-3,1-bezoxazine-2,4(1H)-dione (18.3 g, 103 mmol) containing (2,4-dimethoxy-benzylamino)-acetic acid (25.6 g, 114 mmol) in p-xylene (125 mL) was heated under reflux (150° C.) for 2.5 h. After cooling to room temperature the precipitate was filtered off and washed with p-xylene (2×20 ml). Yield: 34.1 g (97%). m/z 341 (MH+).

1. temperaturewas heated
2. temperatureAfter cooling to room temperature the precipitate
3. filtrationwas filtered off
4. washwashed with p-xylene (2×20 ml)