反应详情

温度

150 °C

A suspension of 6-isopropyl-1H-benzo[d][1,3]oxazine-2,4-dione (3.0 g, 15 mmol) containing (2,4-dimethoxy-benzylamino)-acetic acid (3.7 g, 16 mmol) in p-xylene (40 mL) was heated under reflux (150° C.) for 2.5 h. After cooling to room temperature the precipitate was filtered off and washed with p-xylene (2×20 ml). Yield: 4.9 g (90%). m/z 367 (M—H−).

1. temperaturewas heated
2. temperatureAfter cooling to room temperature the precipitate
3. filtrationwas filtered off
4. washwashed with p-xylene (2×20 ml)