反应详情

温度

150 °C

A suspension of 6-bromo-2H-3,1-bezoxazine-2,4(1H)-dione (22.0 g, 91 mmol) containing (2,4-dimethoxy-benzylamino)-acetic acid (22.5 g, 100 mmol) in p-xylene (200 mL) was heated under reflux (150° C.) for 1 h. After cooling to room temperature the precipitate was filtered off and washed with p-xylene (100 ml). Yield: 33.5 g (91%) m/z 403/405 (M).

1. temperaturewas heated
2. temperatureAfter cooling to room temperature the precipitate
3. filtrationwas filtered off
4. washwashed with p-xylene (100 ml)