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0 °C

3-(3-Cyclopropyl-[1,2,4]oxadiazol-5-yl)-5-(2,4-dimethoxy-benzyl)-8-methoxy-4,5-dihydro-2,5,10b-triaza-benzo[e]azulen-6-one (5 g, 10.3 mmol) were dissolved in CH2Cl2 (30 mL), cooled to 0° C., then TFA (30 mL) was added, followed by trifluoromethanesulfonic acid (2 mL, 22.9 mmol). The mixture was stirred for 4 h at rt, evaporated, the residue dissolved in CH2Cl2 (100 mL), and extracted with 10% NaHCO3. The product precipitated upon evaporation of CH2Cl2. Yield: 3 g (86%); mp 245° C. m/z 337 (M).

1. customevaporated
2. dissolutionthe residue dissolved in CH2Cl2 (100 mL)
3. extractionextracted with 10% NaHCO3
4. customThe product precipitated upon evaporation of CH2Cl2