反应详情

温度

150 °C

A suspension of 6-methylsulfanyl-1H-benzo[d][1,3]oxazine-2,4-dione (4.8 g, 23 mmol) containing (2,4-dimethoxy-benzylamino)-acetic acid (5.6 g, 25 mmol) in p-xylene (50 mL) was heated under reflux (150° C.) for 3 h. After cooling to room temperature the precipitate was filtered off and washed with p-xylene (2×20 ml). Yield: 7.5 g (89%). m/z 373 (MH+).

1. temperaturewas heated
2. temperatureAfter cooling to room temperature the precipitate
3. filtrationwas filtered off
4. washwashed with p-xylene (2×20 ml)