Phosphorus oxychloride → HCID 22713467, compound

Participants

Reaction Steps

8-Chloro-5-(2,4-dimethoxy-benzyl)-6-oxo-5,6-dihydro-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid amide (5.9 g, 13.8 mmol) and phosphorous oxychloride (1.4 mL, 15.2 mmol) were mixed in dioxane (55 mL) and refluxed overnight. The resulting yellow solution was evaporated and the residue purified by chromatography on silica gel in CH2Cl2/acetone 20:1. One obtained a white foam (3.5 g, 61%). m/z 408 (MH+)

Provenance & Evidence