Hydrazine → HCID 14230061, compound

HRID 35187Notes

Reaction equation

HRID 35187 reaction equation
[CH3:1][N:2]1[C:7]2[CH:8]=[CH:9][C:10]([C:12](=O)[CH:13]([CH3:19])[CH2:14][C:15](OC)=[O:16])=[CH:11][C:6]=2[S:5][CH2:4][C:3]1=[O:21].[NH2:22][NH2:23]>C(O)C>[CH3:1][N:2]1[C:7]2[CH:8]=[CH:9][C:10]([C:12]3[CH:13]([CH3:19])[CH2:14][C:15](=[O:16])[NH:22][N:23]=3)=[CH:11][C:6]=2[S:5][CH2:4][C:3]1=[O:21]

Participants

4

Reactant 2

HCID 9321HydrazineHCID 15035924Methyl 4-(3,4-dihydro-4-methyl-3-oxo-1,4[2H]-benzothiazin-7-yl)-3-methyl-4-oxobutyrate

Product 1

HCID 14230061HCID 14230061, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 4-(3,4-dihydro-4-methyl-3-oxo-1,4[2H]-benzothiazin-7-yl)-4-oxo-3-methylbutyrate (1.7 g) was heated at reflux overnight with 0.3 ml of hydrazine in 50 ml of ethanol. Filtration gave a white powder which was chromatographed on silica gel eluted with 5% methanol in methylene chloride, yielding 110 mg of the named compound, mp 193°-194.5° C.

Workup

  1. filtrationFiltration
  2. customgave a white powder which
  3. customwas chromatographed on silica gel
  4. washeluted with 5% methanol in methylene chloride

Sources & evidence

ORD record
ord-ade7a0bdc24640cf84f2d91c5c788b55
Source dataset
uspto-grants-1988_08
Patent number
US04766118

Reaction notes

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