HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl dithioacetate → 5-(S)-Thioacetamidomethyl-3-[4'-ethylsulfinyl-3'-fluorophenyl]oxazolidine-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl dithioacetate | HCID 70093 | — |
| Reactant | 5-(S)-Aminomethyl-3-[4'-ethylsulfinyl-3'-fluorophenyl]oxazolidine-2-one | HCID 22966199 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(S)-Thioacetamidomethyl-3-[4'-ethylsulfinyl-3'-fluorophenyl]oxazolidine-2-one | HCID 9928106 | — |
Reaction Steps
Prepared analogously to the Method A of General Methods of Preparation of 5-(S)-Thioamidomethyloxazolidinones (Example 1) from 5-(S)-aminomethyl-3-[4′-ethylsulfinyl-3′-fluorophenyl]oxazolidine-2-one (0.0885 g, 0.309 mmol) and ethyl dithioacetate. Reaction was performed in DMF overnight. Yield 0.104 g (98%). M.p. 138-9° C. MS (m/z): [M+H]+=345.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743811B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-4a66ff8d612f461bb857e7a9033e4dc2 |
| Source note | uspto-grants-2004_06 |