HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → 5-(S)-Aminomethyl-3-[4'-(2''-fluoroethyl)sulfinyl-3'-fluorophenyl]oxazolidine-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | 5-(S)-aminomethyl-3-[4'-methylsulfinyl-3'-fluorophenyl]oxazolidine-2-one | HCID 22966200 | — |
| Reactant | 5-(S)-Azidomethyl-3-[4'-(2''-fluoroethyl)sulfinyl-3'-fluorophenyl]oxazolidine-2-one | HCID 86586393 | — |
| Product | 5-(S)-Aminomethyl-3-[4'-(2''-fluoroethyl)sulfinyl-3'-fluorophenyl]oxazolidine-2-one | HCID 59905871 | — |
Reaction Steps
This compound was prepared analogously to the synthesis of 5-(S)-aminomethyl-3-[4′-methylsulfinyl-3′-fluorophenyl]oxazolidine-2-one from 5-(S)-azidomethyl-3-[4′-(2″-fluoroethyl)sulfinyl-3′-fluorophenyl]oxazolidine-2-one (0.275 g, 0.833 mmol) and triphenylphosphine (0.229 g, 0.874 mmol). Yield 0.253 g (80%). MS (m/z): [M+H]+=305.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743811B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-6f73ae2c7ae84816954a1111952d207a |
| Source note | uspto-grants-2004_06 |