HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl dithioacetate → 5-(S)-Thioacetamidomethyl-3-[4'-(2''-fluoroethyl)sulfinyl-3'-fluorophenyl]-oxazolidine-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl dithioacetate | HCID 70093 | — |
| Reactant | 5-(S)-Aminomethyl-3-[4'-(2''-fluoroethyl)sulfinyl-3'-fluorophenyl]oxazolidine-2-one | HCID 59905871 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 5-(S)-Thioacetamidomethyl-3-[4'-(2''-fluoroethyl)sulfinyl-3'-fluorophenyl]-oxazolidine-2-one | HCID 9863788 | — |
Reaction Steps
Prepared analogously to the Method A of General Methods of Preparation of 5-(S)-Thioamidomethyloxazolidinones (Example 1) from 5-(S)-aminomethyl-3-[4′-(2″-fluoroethyl)sulfinyl-3′-fluorophenyl]oxazolidine-2-one (0.100 g, 0.329 mmol) and ethyl dithioacetate. Reaction was performed in DMF overnight. Yield 0.114 g (96%). M.p. 161° C. MS (m/z): [M+H]+=363.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743811B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-ebb832f7a7b64f989995cc056daf869e |
| Source note | uspto-grants-2004_06 |