HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → HCID 17958793, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | HCID 69869710 | HCID 69869710 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | HCID 17958793 | HCID 17958793 | — |
Reaction Steps
60 mg (94 μmol) of 26 are dissolved in 5 ml of acetone and hydrogenated for 10 hours at RT and atmospheric pressure in the presence of 40 mg (0.48 mmol) of sodium hydrogen carbonate and 20 mg of palladium/activated carbon (10%). Removal of the catalyst by filtration and evaporation of the solution gives 3-(4-fluorophenyl)-3-{6-[3-(pyridin-2-ylamino)propoxy]indol-3-yl}propionic acid. Preparative HPLC on RP-18 gives 3-(4-fluorophenyl)-3-{6-[3-(pyridin-2-ylamino)propoxy]indol-3-yl}propionic acid trifluoroacetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743810B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-b76e5b82239340659401cbb7d884af48 |
| Source note | uspto-grants-2004_06 |