HCID 69870404, compound → HCID 178525332, compound

HRID 351935Notes

Reaction equation

HRID 351935 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][O:5][C:6]1[CH:14]=[C:13]2[C:9]([C:10]([CH:15]([C:20]3[CH:21]=[CH:22]C4[C:24]([CH:28]=3)=[N:25]SN=4)[CH2:16][C:17]([OH:19])=[O:18])=[CH:11][NH:12]2)=[CH:8][CH:7]=1.CS[C:31]1[NH:32][CH2:33][C:34](=[O:36])[N:35]=1>>[O:36]=[C:34]1[CH2:33][NH:32][C:31]([NH:1][CH2:2][CH2:3][CH2:4][O:5][C:6]2[CH:14]=[C:13]3[C:9]([C:10]([CH:15]([C:20]4[CH:21]=[CH:22][N:25]=[CH:24][CH:28]=4)[CH2:16][C:17]([OH:19])=[O:18])=[CH:11][NH:12]3)=[CH:8][CH:7]=2)=[N:35]1

Participants

3

Reactant 2

HCID 69870404HCID 69870404, compoundHCID 178503564HCID 178503564, compound

Product 1

HCID 178525332HCID 178525332, compound

Procedure

Analogously to Example 16, the reaction of 3-[6-(3-aminopropoxy)-1H-indol-3-yl]-3-benzo-1,2,5-thiadiazol-5-ylpropionic acid (prepared analogously to Example 1.1-1.2 and 15) with 2-methylsulfanyl-1,5-dihydroimidazol-4-one and subsequent synthesis sequence gives

Workup

  1. customgives

Sources & evidence

ORD record
ord-9d17c292de514d7984f732c454751e41
Source dataset
uspto-grants-2004_06
Patent number
US06743810B2

Reaction notes

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