HCID 22714497, compound → HCID 22714545, compound

HRID 351937Notes

Reaction equation

HRID 351937 reaction equation
C([O:3][C:4]([CH2:6][CH:7]([C:28]1[CH:38]=[CH:37][C:31]([C:32]([O:34]CC)=[O:33])=[CH:30][CH:29]=1)[C:8]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)=[CH:14][CH:15]=2)[NH:10][CH:9]=1)=[O:5])C>O1CCOCC1>[C:4]([CH2:6][CH:7]([C:28]1[CH:38]=[CH:37][C:31]([C:32]([OH:34])=[O:33])=[CH:30][CH:29]=1)[C:8]1[C:16]2[C:11](=[CH:12][C:13]([O:17][CH2:18][CH2:19][CH2:20][NH:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)=[CH:14][CH:15]=2)[NH:10][CH:9]=1)([OH:5])=[O:3]

Participants

3

Reactant 1

HCID 22714497HCID 22714497, compound

Product 1

HCID 22714545HCID 22714545, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Analogously to Example 1.7, ethyl 4-(2-ethoxycarbonyl-1-{6-[3-(pyridin-2-ylamino)propoxy]-1H-indol-3-yl}ethyl)benzoate, prepared analogously to Example 1.1-1.6, is stirred with dioxane/1N NaOH, giving 4-(2-carboxy-1-{6-[3-(pyridin-2-ylamino)propoxy]-1H-indol-3-yl}ethyl)benzoic acid.

Sources & evidence

ORD record
ord-ef8e9398e54e46cdb8834613b116af17
Source dataset
uspto-grants-2004_06
Patent number
US06743810B2

Reaction notes

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