5-Amino-6-(2-methoxy-4-methanesulfonylaminobenzoyl-amino)-2-pyridone → HCID 178493306, compound

HRID 35199Notes

Reaction equation

HRID 35199 reaction equation
[NH2:1][C:2]1[CH:3]=[CH:4][C:5](=[O:24])[NH:6][C:7]=1[NH:8][C:9](=O)[C:10]1[CH:15]=[CH:14][C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])=[CH:12][C:11]=1[O:21][CH3:22]>C(O)(=O)C>[CH3:22][O:21][C:11]1[CH:12]=[C:13]([NH:16][S:17]([CH3:20])(=[O:19])=[O:18])[CH:14]=[CH:15][C:10]=1[C:9]1[N:8]=[C:7]2[NH:6][C:5](=[O:24])[CH2:4][CH:3]=[C:2]2[N:1]=1

Participants

3

Reactant 1

HCID 212957955-Amino-6-(2-methoxy-4-methanesulfonylaminobenzoyl-amino)-2-pyridone

Product 1

HCID 178493306HCID 178493306, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

2.7 g of 5-amino-6-(2-methoxy-4-methanesulfonylaminobenzoyl-amino)-2-pyridone were refluxed in 50 acetic acid for 1.5 hours. The mixture was then concentrated by evaporation in vacuo, and the residue was purified on silica gel (eluant: methylene chloride/ethanol 1:0 to 1:0.1). Yield: 0.1 g (4% of theory). Melting point: above 255° C.

Workup

  1. concentrationThe mixture was then concentrated by evaporation in vacuo
  2. customthe residue was purified on silica gel (eluant: methylene chloride/ethanol 1:0 to 1:0.1)

Sources & evidence

ORD record
ord-782ca84b3ffc46adb38a271613f1d9d8
Source dataset
uspto-grants-1988_08
Patent number
US04766130

Reaction notes

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