HCID 69910017, compound → HCID 54295887, compound

HRID 352004Notes

Reaction equation

HRID 352004 reaction equation
[NH2:1][C@@:2]1([N:28]2[CH2:36][C:34](C(OC)C3C=CC=CC=3)([CH3:35])[C:32](=[O:33])[NH:31][C:29]2=[O:30])[O:18][C@H:6]([CH:7](C(OC)C2C=CC=CC=2)[OH:8])[C@@:4](C(OC)C2C=CC=CC=2)([OH:5])[CH2:3]1>[Pd].C(O)C>[NH2:1][C@@:2]1([N:28]2[CH:36]=[C:34]([CH3:35])[C:32](=[O:33])[NH:31][C:29]2=[O:30])[O:18][C@H:6]([CH2:7][OH:8])[C@@H:4]([OH:5])[CH2:3]1

Participants

4

Reactant 1

HCID 69910017HCID 69910017, compound

Product 1

HCID 54295887HCID 54295887, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A suspension of 1′-amino-3′,5′,5-tris(methoxybenzyl)thymidine and 10% palladium on charcoal in ethanol is shaken in a hydrogenation apparatus under hydrogen pressure of 50 psi for 24 h. The solid is filtered and the filtrate concentrated. The crude is purified by recrystallization.

Workup

  1. filtrationThe solid is filtered
  2. concentrationthe filtrate concentrated
  3. customThe crude is purified by recrystallization

Sources & evidence

ORD record
ord-0ad89bf0c63f405e9fa6540f218e9561
Source dataset
uspto-grants-2004_06
Patent number
US06743902B1

Reaction notes

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