Nitric Acid → HCID 178433492, compound

HRID 352005Notes

Reaction equation

HRID 352005 reaction equation
[OH:1][C:2]1[C:7]([CH3:8])=[C:6]([CH3:9])[NH:5][C:4](=[O:10])[CH:3]=1.[N+:11]([O-])([OH:13])=[O:12]>C(O)(=O)C>[OH:10][C:4]1[C:3]([N+:11]([O-:13])=[O:12])=[C:2]([OH:1])[C:7]([CH3:8])=[C:6]([CH3:9])[N:5]=1

Participants

4

Reactant 2

HCID 944Nitric AcidHCID 547235564-Hydroxy-5,6-dimethylpyridin-2(1H)-one

Product 1

HCID 178433492HCID 178433492, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

The above nitration process was essentially repeated using 23.612 g 4-hydroxy-5,6-dimethyl-2(1H)-pyridone, 460 ml acetic acid, 12.2 ml nitric acid, and cooling the mixture in an ice bath after refluxing and prior to filtration. Combined product was used in the next step.

Workup

  1. temperaturecooling the mixture in an ice bath
  2. temperatureafter refluxing
  3. filtrationto filtration

Sources & evidence

ORD record
ord-b5a3add3c6174bcebdfbf0384bba3a4c
Source dataset
uspto-grants-2004_06
Patent number
US06743920B2

Reaction notes

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