反应详情

The above nitration process was essentially repeated using 23.612 g 4-hydroxy-5,6-dimethyl-2(1H)-pyridone, 460 ml acetic acid, 12.2 ml nitric acid, and cooling the mixture in an ice bath after refluxing and prior to filtration. Combined product was used in the next step.

1. temperaturecooling the mixture in an ice bath
2. temperatureafter refluxing
3. filtrationto filtration