反应详情

A solution of potassium hydroxide (6.52 g, 0.116 mol, 1.2 equiv.) in 970 mL of absolute ethanol was treated with N-benzyloxycarbonyl-3(S)-amino-1-chloro-4-phenyl-2(s)-butanol (32.3 g, 0.097 mol). This solution was stirred at room temperature for 15 min and then concentrated in vacuo to give a white solid. The solid was dissolved in dichloromethane and washed with water, dried over anhyd MgSO4, filtered and concentrated in vacuo to give a white solid. The solid was crystallized from hexanes and ethyl acetate to give 22.3 g, 77% of N-benzyloxycarbonyl-3(S)-amino-1,2(S)epoxy-4-phenylbutane, mp 102-103° C., FAB MS: MH+=298.

1. concentrationconcentrated in vacuo
2. customto give a white solid
3. washwashed with water
4. dry with materialdried over anhyd MgSO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo
7. customto give a white solid
8. customThe solid was crystallized from hexanes and ethyl acetate