反应详情

To a solution of 1.2 equiv. of potassium hydroxide in 968 mL of absolute ethanol at room temperature, is added 0.097 mol of N-CBZ-3(S)-amino-1-chloro-4-phenyl-2(S)-butanol. After stirring for fifteen minutes, the solvent is removed under reduced pressure and the solids are dissolved in methylene chloride. After washing with water, drying over magnesium sulfate, filtering and stripping, one obtains a white solid. Recrystallization from hot ethyl acetate and hexane will afford N-benzyloxycarbonyl-3(S)-amino-1,2(S)-epoxy-4-phenylbutane.

1. customthe solvent is removed under reduced pressure
2. dissolutionthe solids are dissolved in methylene chloride
3. washAfter washing with water
4. dry with materialdrying over magnesium sulfate
5. filtrationfiltering
6. customone obtains a white solid
7. customRecrystallization from hot ethyl acetate and hexane