反应详情

Tosylhydrazine (234 g, 1.26 mol) was suspended in propionic acid (2 L) and dichloroacetaldehyde (142 g, 1.26 mol) was added at 15-20° C. The mixture was stirred at room temperature for 2 hours and under ice-cooling for 3 hours. The precipitated crystals were collected by filtration and washed with toluene. The crystals were dried under reduced pressure to give 2,2-dichloroacetaldehyde tosylhydrazone (247 g, yield 70%).

1. temperaturecooling for 3 hours
2. filtrationThe precipitated crystals were collected by filtration
3. washwashed with toluene
4. customThe crystals were dried under reduced pressure