Water → HCID 69829475, compound

Participants

Reaction Steps

A solution of the product from Example 22 step (b) (0.20 g, 0.61 mmol), 1-tert-butoxycarbonylpiperazine (0.34 g, 1.83 mmol) and potassium iodide (0.051 mg, 0.31 mmol) in N-methylpyrrolidine was heated to 100° C. in a sealed vessel and stirred for 4 h. The reaction was cooled and poured into water (50 ml) and the mixture extracted with ethyl acetate (3×50 ml). The combined organic extracts were washed with water (3×30 ml), dried (magnesium sulphate) and evaporated to leave an oily residue (0.20 g, 70%).

Provenance & Evidence