1,1-Dibromoethane → 1-(3-Thienyl)-1,4-butanediol

3-Chloropropanol (6.77 ml, 81 mmol) was dissolved in anhydrous tetrahydrofuran (100 ml) and the solution cooled to 0° C. i-Propyl magnesium chloride, 2M solution, (40.5 ml, 81 mmol) was added dropwise, keeping the temperature at 0° C. When the addition was complete the reaction was allowed to warm to room temperature. Magnesium (2.96 g, 122 mmol) was added in one portion, followed by dibromoethane (0.1 ml). The reaction was heated and gently refluxed for 3 h, adding more dibromoethane (0.1 ml) at 1 and 2 h. The reaction was cooled and left to stand overnight. The resultant Grignard solution was titrated and had a concentration of 0.4M. The Grignard reagent prepared above (30 ml, 12 mmol) was syringed into a nitrogen flushed 3-necked flask, cooled to 0° C. and treated dropwise with 3-thiophene carboxaldehyde (1.12 g, 10 mmol) in tetrahydrofuran (10 ml). The reaction was allowed to warm to room temperature slowly and then stirred for a further 18 h. Saturated aqueous ammonium chloride (20 ml) was added and the mixture extracted with ethyl acetate (3×75 ml). The combined organic extracts were washed with water (20 ml), dried (magnesium sulphate) and evaporated to afford the title compound as a colourless oil (1.52 g, 88%).

1. additionwas added dropwise
2. customat 0° C
3. additionWhen the addition
4. temperatureThe reaction was heated
5. temperaturegently refluxed for 3 h
6. temperatureThe reaction was cooled
7. waitleft
8. customwas syringed into a nitrogen flushed 3-necked flask
9. temperaturecooled to 0° C.
10. temperatureto warm to room temperature slowly
11. extractionthe mixture extracted with ethyl acetate (3×75 ml)
12. washThe combined organic extracts were washed with water (20 ml)
13. dry with materialdried (magnesium sulphate)
14. customevaporated

ORD record

ord-cd6a17614d9442a0b2b4b0ae293baccc

Source dataset

uspto-grants-2004_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06743939B2