Methyl iodide → HCID 131724447, compound

Participants

Reaction Steps

The product of Example 41 step (c) (0.68 g) was dissolved in dry tetrahydrofuran (40 ml) and treated with sodium hydride (60% dispersion in oil, 0.3 g) and stirred under nitrogen for 0.5 h. Methyl iodide (3 ml) was added and the reaction mixture stirred at ambient temperature for 48 h. The mixture was then cooled in an ice-bath and carefully treated with saturated ammonium chloride (50 ml) and extracted into ethyl acetate. The organic extract was washed with water, brine, dried over magnesium sulphate and evaporated to give a yellow oil (0.7 g).

Provenance & Evidence