HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → HCID 20729734, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | HCID 22713779 | HCID 22713779 | — |
| Catalyst | 4-(Dimethylamino)pyridine | HCID 14284 | — |
| Solvent | Propan-2-one--dichloromethane (1/1) | HCID 21584124 | — |
| Product | HCID 20729734 | HCID 20729734 | 62% |
Reaction Steps
In a fashion similar to that described for preparation 108, a compound from preparation 105(0.1 g, 0.3 mmol), TFA (2 mL), dichloro-methane (1.5 mL), EDCI (0.086 g, 0.45 mmol), DMAP (0.007 g, 0.06 mmol), 3-(2-fluoro-3-iodo-phenyl)-5-methyl-isoxazole-4-carboxylic acid (0.125 g, 0.36 mmol), and dichloromethane (1.5 mL) gave the title compound (0.104 g, 62%) after column chromatography (silica gel, acetone/dichloromethane gradient). Mass Spectrum (FIA) (m/z) 562.1 [M+1].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743794B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-20779897cc4a4e1ea48e59e6a5ada86b |
| Source note | uspto-grants-2004_06 |