2-Chloro-6-fluorobenzaldehyde → HCID 69848728, compound

HRID 352174Notes

Reaction equation

HRID 352174 reaction equation
Cl.[C:2]([NH:6][NH2:7])([CH3:5])([CH3:4])[CH3:3].[Cl:8][C:9]1[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[C:10]=1[CH:11]=O>C(O)(=O)C>[ClH:8].[C:2]([NH:6][N:7]=[CH:11][C:10]1[C:13]([F:17])=[CH:14][CH:15]=[CH:16][C:9]=1[Cl:8])([CH3:5])([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 678472-Chloro-6-fluorobenzaldehydeHCID 81889tert-Butylhydrazine monohydrochloride

Product 1

HCID 69848728HCID 69848728, compoundYield 61%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of t-butyl hydrazine hydrochloride (1.24 g, 10 mmol) and 2-chloro-6-fluorobenzaldehyde (1.1 mL, 10 mmol) dissolved in acetic acid (5 mL) was stirred at 50° C. for half hour. Hexanes (10 mL) was added, filtered and washed the white solid with hexanes (20 mL). Yield: 61%. ESMS: 229 (M+1).

Workup

  1. filtrationfiltered
  2. washwashed the white solid with hexanes (20 mL)

Sources & evidence

ORD record
ord-26cda6d9354c41d4994ad6097e8b696d
Source dataset
uspto-grants-2004_06
Patent number
US06743794B2

Reaction notes

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