HCID 69849151, compound → HCID 22713823, compound

Participants

Reaction Steps

A solution of [3-(9-Chloro-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)-cyclohexylmethyl]-carbamic acid benzyl ester (0.5 g, 1.04 mmol) and Mo(CO)6 (3.0 g, 0.01 mmol) in Acetonitrile (50 mL) and water (5 mL) was heated to 60° C. and stirred overnight. The reaction was concentrated to a solid, diluted in CH2Cl2 and filtered through Celite to remove the black insoluble material. The filtrate was concentrated to a solid and purified using silica gel column chromatography. The product was eluted with 10% EtOAc in CH2Cl2. The solvent was removed to afford 0.520 g (quantitative) of product as a light brown oil. MS (ES+) m/z 482.0 (M+H)+,(ES−) m/z 479.9 (M−H)−, 540.0 (M+CH3COO−)−.

Provenance & Evidence