HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 22714015, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | Propan-2-one--dichloromethane (1/1) | HCID 21584124 | — |
| Reactant | HCID 22713868 | HCID 22713868 | — |
| Reactant | HCID 131724454 | HCID 131724454 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 22714015 | HCID 22714015 | 90% |
Reaction Steps
In a fashion similar to that described for preparation 267, 4-carboxy-5-chloro-3-(2-chloro-5-fluorophenyl)isoxazole acid (0.22 g, 0.84 mmol), dichloromethane (2 ml), oxalyl chloride (0.15 ml, 1.68 mmol), DMF (0.01 ml), dichloromethane (5 ml), N-(3-Amino-cyclohexylmethyl)-benzamide (0.15 g, 0.65 mmol), and triethylamine (0.35 ml, 2.52 mmol) gave the title compound (0.29 g, 90%) after flash chromatography (silica gel, Acetone/CH2Cl2 gradient). Mass Spectrum (ES+) (m/z) 490.1 [M+1].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743794B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-0481027a2f3247178a28ab4051e0192a |
| Source note | uspto-grants-2004_06 |