HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 69848343, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Acetonitrile | HCID 6342 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Propan-2-one--dichloromethane (1/1) | HCID 21584124 | — |
| Reactant | HCID 22714005 | HCID 22714005 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | HCID 69848343 | HCID 69848343 | 83% |
Reaction Steps
In a fashion similar to that described for Example 592, N-[3-(6-Iodo-3-methyl-4-oxo-5H-isoxazolo[4,3-c]quinolin-5-yl)-cyclohexylmethyl]-benzamide (0.048 g, 0.089 mmol), acetonitrile (10 ml), MeOH (5 ml), Et3N (0.04 ml, 0.267 mmol), and PdCl2(dppf) (0.004 g, 0.004 mmol) gave the title compound (0.035 g, 83%) after column chromatography (silica gel, acetone/dichloromethane gradient). MS(FIA) (m/z) 472.3 [M−1].
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743794B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-adf265608bff4364b9ef4a61fd4db503 |
| Source note | uspto-grants-2004_06 |