HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → 5-(3-Amino-cyclohexyl)-9-chloro-3-methyl-5H-isoxazolo[4,3-c]quinolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 5-(3-Aminocyclohexyl)-9-chloro-3-methyl-5H-isoxazolo[4,3-c]quinolin-4-one hydroiodide | HCID 22713713 | — |
| Product | 5-(3-Amino-cyclohexyl)-9-chloro-3-methyl-5H-isoxazolo[4,3-c]quinolin-4-one | HCID 22713714 | 98% |
Reaction Steps
A compound from Example 634 (350 mg,0.95 mmol) was treated with excess aqueous NaHCO3 and the mixture extracted with EtOAc. The combined extracts were dried over Na2SO4 and concentrated in vacuo to yield 309 mg (98%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06743794B2 |
| Source dataset | uspto-grants-2004_06 |
| ORD ID | ord-f1f4016b20b04d1a86714a40492d5889 |
| Source note | uspto-grants-2004_06 |