Methanol → HCID 22713956, compound

HRID 352239Notes

Reaction equation

HRID 352239 reaction equation
[N-:1]=[C:2]=[O:3].[Cl:4][C:5]1[C:6]2[C:7]3[C:8](=[C:27]([CH3:30])[O:28][N:29]=3)[C:9](=[O:26])[N:10]([CH:15]3[CH2:21][CH2:20][CH2:19][CH2:18][CH:17]([CH2:22]C(O)=O)[CH2:16]3)[C:11]=2[CH:12]=[CH:13][CH:14]=1.[CH3:31][OH:32]>>[CH3:31][O:32][C:2](=[O:3])[NH:1][CH2:22][CH:17]1[CH2:18][CH2:19][CH2:20][CH2:21][CH:15]([N:10]2[C:11]3[CH:12]=[CH:13][CH:14]=[C:5]([Cl:4])[C:6]=3[C:7]3=[N:29][O:28][C:27]([CH3:30])=[C:8]3[C:9]2=[O:26])[CH2:16]1

Participants

4

Reactant 3

HCID 887MethanolHCID 105034IsocyanateHCID 22713748HCID 22713748, compound

Product 1

HCID 22713956HCID 22713956, compound

Procedure

In a manner similar to the preparation of Example 677 (except the intermediate isocyanate was trapped with MeOH instead of TMS ethanol) 0.68 g (1.8 mmols) of a compound from Example 680 was converted to 0.43 g of the title compound.

Sources & evidence

ORD record
ord-0def6c99aedb4eb7997bdfec6b4f14f6
Source dataset
uspto-grants-2004_06
Patent number
US06743794B2

Reaction notes

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