HCID 69849118, compound → HCID 22714176, compound

Participants

Reaction Steps

A solution of {1-[3-(9-Chloro-3-methyl-4-oxo5H-isoxazolo[4,3-c]quinolin-5-yl)-cyclohexylcarbamoyl]-2-hydroxy-ethyl}-carbamic acid tert-butyl ester, 73 mg (0.14 mmol) in 8 mL of 25% TFA in CH2Cl2 was stirred rt. for three hours then concentrated to dryness. The residue was partitioned between 20% isopropanol/chloroform and saturated aqueous NaHCO3. The organics were washed with saturated NaHCO3, washed with brine, dried over Na2SO4, filtered and concentrated to dryness. The residue was purified by radial chromatography using MeOH/chloroform as eluent and concentrated to dryness to yield 40 mg (69%) of the title compound as a white solid. 1H—NMR is consistent with structure. MS (IS) 419.1 (M+).

Provenance & Evidence